Capsules are used extensively in the pharmaceutical industry. It has the advantages of convenient and easy to take, reducing the stimulation of the ingredients on the stomach and masking the bad smell of the drug.

Capsules have become one of the main dosage forms of oral solid preparations other than tablets. Medicinal gelatin empty capsule is a special kind of medicinal excipient, which enters the digestive system of the human body together with the medicine and is finally absorbed by the human body. Therefore, the quality is directly related to the safety of the medicine. The quality of gelatin and the standardization of its production process are the main factors affecting the safety of empty capsules.

Although industrial gelatin and medicinal gelatin are not fundamentally different, industrial gelatin is definitely not used in the pharmaceutical industry. So how do we distinguish between these two gelatins?

Gelatin is a product obtained by partially hydrolyzing collagen obtained from the skin of an animal, connecting tissues and bone. Its main ingredient is protein. It has many excellent physical and chemical properties, such as adhesion, surface activity and the like. Depending on the application, gelatin can be divided into edible gelatin, medicinal gelatin, lighting gelatin and industrial gelatin.

The hard gelatin capsule is a dosage form prepared by filling an appropriate amount of the medicinal material extracts or the auxiliary material into a hard capsule. The soft gelatin capsule is a dosage form prepared by sealing a liquid drug or a suspension which does not dissolve the oil or a capsule material such as gelatin in the capsule.

Ethylene oxide is an efficient and broad-spectrum gas sterilizer with strong volatility and strong penetrability. It can penetrate polyethylene film in 5 seconds. Ethylene oxide can react with microbial proteins, DNA, and RNA to kill microorganisms, is therefore widely used for sterilization of medical devices and plastic products.

Food grade H2O2, as a disinfectant, bleaching agent, etc., is widely used in food processing such as dairy products and dried bean curd. The Ministry of Health GB2760-1996 has strict control over the scope, area and dosage of H2O2, and it is not allowed to detect it in the final product.

Gelatin is a collagen in the skin, bone and tendons of animals. After partial hydrolysis, the protein product obtained by purification is also a good microbial culture medium under a certain water content. Therefore, microbial control of gelatin products is critical.

Sulfite is used as a preservative, bleach, color retention agent, bulking agent, reducing agent in the food and drug industry, and has excellent food modification effects. However, long-term excessive intake of sulfites can produce a variety of toxicities.

Heavy metals generally refer to Hg, Cd, Pb, Cr, And metalloids with significant biotoxicity and heavy metal properties, such as As. and are sometimes referred to as general heavy metals such as Cu, Zn, Co, and Ni.