The molecular weight ranges from 10,000 to 1,500,000. Hypromellose is divided into four subtypes depending on the content of methoxy and hydroxypropoxy groups, namely, 1828, 2208, 2906, and 2910. Calculating the dried product, the content of each substituted methoxy (-OCH3) and hydroxypropoxy (-OCH2CHOHCH3) should be in accordance with the following table.

This standard specifies the specifications, technical indicators and requirements, test methods, inspection rules, criterion rule and requirements of product packaging, labeling, transportation and storage of empty HPMC capsules.This standard is applicable to empty HPMC hard capsules made of HPMC and auxiliary materials and HPMC should meet relevant requirements.

Pharmaceutical preparations are inseparable from pharmaceutical excipients. The improvement of the quality of pharmaceutical preparations and the emergence of new dosage forms are often based on the development of new excipients. As one of the most widely used pharmaceutical excipients, HPMC can be used as an adhesive, a disintegrant, a sustained release agent, a coating film former, etc. due to its molecular weight and viscosity.

HPMC is the abbreviation of Hydroxy Propyl Methyl Cellulose. Hydroxypropyl methylcellulose is an odorless, non-toxic white powder that dissolves in cold water to form a clear, viscous solution. HPMC has thickening ability, salt discharge, pH stability, water retention, dimensional stability, excellent film formation and a wide range of enzyme resistance, dispersibility and adhesion. It is widely used in construction materials, coatings, synthetic resins, ceramics, medicine, food, textile, agriculture, cosmetics, tobacco and other industries.

Cellulose is a natural polymer compound whose chemical structure is a polysaccharide macromolecule taking anhydrous β-glucose as the main component. A series of cellulose derivatives can be obtained by chemical modification, and Cellulose Ether is one of them.

In general, qualified capsules should be completely dissolved within 15 minutes of shaking in water at 37 ° C, which is similar to the dissolution time of ordinary tablets. Therefore, in general, it can dissolve quickly in the body temperature environment.

As the wide usage of the gelatin, some of its problems were gradually revealed. Therefore, many experts started to look for a new alternative for capsule material, which would be safer and healthier. HPMC (HYDROXYPROPYL METHYLCELLULOSE) is one of the suitable alternatives, and then it comes out HPMC capsule.